Bromopyridazinedione-mediated protein and peptide bioconjugation† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc12807h Click here for additional data file.

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc11114k Click here for additional data file.

Controlling maleimide hydrolysis allows the modular construction of bromomaleimide-mediated bioconjugates which are either stable or cleavable in an aqueous, thiol-mediated reducing environment. The application of this methodology to reversible protein biotinylation, the irreversible labeling of peptide disulfide bonds and the assembly of stable, fluorescein-labelled glycoprotein mimics is desc...

Controlled levels of protein modification through a chromatography-mediated bioconjugation† †Electronic supplementary information (ESI) available: Full experimental procedures and additional characterization data. See DOI: 10.1039/c4sc03790a Click here for additional data file.

Competitive formation of homocircuit [3]rotaxanes in synthetically useful yields in the bipyridine-mediated active template CuAAC reaction† †Electronic supplementary information (ESI) available: Full experimental details and characterisation of all novel compounds. See DOI: 10.1039/c4sc03999h Click here for additional data file.

Novel octavalent cross-linker displays efficient trapping of protein–protein interactions† †Electronic supplementary information (ESI) available: General experimental details and characterisation data for compounds 1–3. See DOI: 10.1039/b701542a Click here for additional data file. Click here for additional data file.

A novel octavalent, resorcin[4]arene derived, cross-linker designed to overcome some of the limitations of commercially available reagents is significantly more efficient for covalent stabilisation of protein-protein interactions.

Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium† †Electronic supplementary information (ESI) available: Materials, full experimental details and characterisation. See DOI: 10.1039/c4sc02889a Click here for additional data file.